Fig 1: The core transcriptional identities of human astrocytes, oligodendrocytes, microglia, and neurons include known and novel biomarkers.A-D) The top 50 genes ranked by consensus expression fidelity for astrocytes, oligodendrocytes, microglia, or neurons. Expression levels represent averages of mean percentile ranks for all regional datasets where gene data were present. Mutation intolerance data were obtained from ExAC35. PubMed citations were obtained by queries with gene symbol and cell type (e.g. gene symbol and ‘astrocyte’). Cellular localization data were extracted from COMPARTMENTS36. Predicted protein-protein interactions (PPI) were obtained from STRING37. A link is shown if the combined score between two proteins was > 350. The probability of observing the number of depicted links by chance was determined by resampling (n = 100,0000 random samples of 50 genes). E-H) Novel markers of human astrocytes (PON2), oligodendrocytes (DBNDD2), microglia (APBB1IP), and neurons (CELF2) in adult human dorsolateral prefrontal cortex (DLPFC; E: L5/6; F,G: white matter; H: L2/3). Immunostaining was repeated at least twice on independent samples with similar results. Arrowhead: cell in inset. Scale bar: 50μm; inset scale bar: 10μm.